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Head and Neck Cancers

CONDITIONS

Head and neck cancers arise in the oral cavity, the pharynx, the larynx, the nose and the paranasal sinuses. They are closely linked to smoking, alcohol and the HPV virus, and when diagnosed early they are treated with very good results.

4 to 5 %of all cancers worldwide, more than 930,000 new cases a year
2 timeshigher risk in men, and in both sexes it rises after 50
5 to 25 timeshigher risk in smokers

Where they occur

Most are squamous cell carcinomas, which develop in the mucous membrane lining these organs. 44 % arise in the oral cavity, 31 % in the larynx and 25 % in the pharynx.

SiteWhat it includesFrequency
Oral cavityLips, tongue, gums, palate, inner surfaces of the mouth.44 %
LarynxVocal cords and the surrounding area.31 %
PharynxNasopharynx, oropharynx, hypopharynx. The oropharynx is particularly linked to HPV.25 %
Nasal cavity and paranasal sinusesThe nose and the sinuses around it.rare

Risk factors

  • Smoking the main cause, 5 to 25 times higher risk
  • Alcohol excessive consumption, especially together with smoking, multiplies the risk
  • HPV virus particularly associated with cancers of the oropharynx
  • Chemicals wood dust, asbestos and other harmful substances at work
  • Oral hygiene poor hygiene contributes to the risk
  • Diet insufficient consumption of fruit and vegetables

Symptoms

Symptoms vary with the site. Any of the following, especially when it persists for more than three weeks, should lead you to a medical assessment, imaging and, if necessary, biopsy.

  • Mouth sores that do not heal
  • Pain or difficulty swallowing
  • A lump in the neck, the throat or the skin
  • Growths in the oral cavity
  • Changes in the voice or hoarseness
  • Persistent bad breath
  • Unexplained weight loss
  • Pain in the ear or the neck
  • Nosebleeds and persistent nasal obstruction

Diagnosis

  1. Clinical examination

    Checking for lumps, sores that do not heal, changes in the voice.

  2. Endoscopy

    Examination of the larynx, the pharynx and areas that are not directly accessible.

  3. Imaging

    CT or MRI and PET scan to map the area and the extent of the disease.

  4. Biopsy

    Tissue sampling and histological analysis, with HPV testing where relevant.

  5. Blood tests

    General health and markers, before treatment planning.

Treatment options

Treatment depends on the site, the stage and the patient’s general health, and often combines more than one method. Modern chemotherapy and radiotherapy give better results with milder side effects.

SurgeryRemoval of the tumour with a margin of healthy tissue and, if needed, of the neck lymph nodes. Resections are less invasive today, and reconstruction techniques allow radical excision with milder disfigurement and a better functional result.
RadiotherapyHigh-energy rays to the cancer cells, alone or in combination. Modern techniques protect the salivary glands and swallowing.
ChemotherapyUsually together with radiotherapy, to increase its effectiveness or to shrink the tumour before surgery.
ImmunotherapyNewer treatments that boost the immune system, with significant results in recurrent and metastatic disease.
Targeted therapiesDrugs against specific molecules of the cancer cells, such as the EGFR receptor.
RehabilitationSpeech therapy, nutritional support and reconstructive procedures for speech, swallowing and appearance.

Prevention

Head and neck cancers are largely prevented by simple changes in everyday habits.

  • Stopping smoking and limiting alcohol
  • Vaccination against the HPV virus
  • A healthy diet with fruit and vegetables
  • Regular and careful oral hygiene, with an annual dental check-up
  • Protection from harmful substances at work

Your care at the 4th Oncology Clinic

Every case is discussed at the Clinic’s tumour board, where medical oncologists, surgeons, radiation oncologists, radiologists and pathologists jointly design the personalised treatment plan. Our patients have access to new treatments through the Clinical Trials Centre and, where there is a family history, to genetic counselling. Meet our team or contact us for an appointment.